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KMID : 0614020060210010079
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Journal of Pharmaceutical Sciences (C.N.U.)
2006 Volume.21 No. 1 p.79 ~ p.87
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Preparation and evaluation of cubosome containing ursolic acid as topical dermal delivery system
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Lee Seung-Yeon
Kyung Ki-Yeol
Lee Jong-Hwa
Jee Ung-Kil
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Abstract
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Nanosized particle of bicontinuous cubic liquid crystalline phase system nominated "cubosome" allows for simultaneous incorporation of water- and oil-soluble materials as well as amphiphiles. The solubilization of ursolic acid, a highly hydrophobic molecule, into a cubosome system was formulated by liquid precursor dilution method. Ursolic acid (UA) with anti-inflammatory and anti-aging effect obtained from some plants. The cubosomes with and without UA were prepared and evaluated. The cubosomes had mean diameter of from 30 to 300 nm. The size increased according as the glyceryl monooleate(GMO) content increased and ratio of poloxamer 407 to water decreased. The turbidity of cubosome increased with increase of GMO content, but the addition of poloxamer 407 reduced the particle size with bluish appearance. Cubosomes from the GMO-ethanol-poloxamer 407-water system were proved relatively stable dispersion system without any creaming and sedimentation for 80 days at various storage temperatures. Viscosity of cubosomes was increased at high concentration of GMO and a rheological property of cubosomes revealed pseudo-plastic flow and weak thixotropic behavior. The percutaneous absorption rate of UA in cubosome system was 2.7 times higher than in liposome system.
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KEYWORD
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cubosome, amphiphiles, liquid precursor, percutaneous absorption, ursolic acid
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